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簡(jiǎn)單介紹：
VCU動(dòng)物顱腦損傷儀可以分為細(xì)胞顱腦損傷儀(CIC)，電子顱腦損傷儀(eCCI)及液壓顱腦損傷儀(FPI)，這三種產(chǎn)品己廣泛應(yīng)用于世界范圍內(nèi)的顱腦創(chuàng)傷研究中心，是目前顱腦創(chuàng)傷模型制作的金標(biāo)準(zhǔn)。
詳情介紹：
創(chuàng)傷性腦損傷(Traumatic Brain Injury,TBI)是神經(jīng)外科常見的病,是導(dǎo)致創(chuàng)傷患者傷殘及死亡的主要原因。研究腦損傷后的神經(jīng)生化、神經(jīng)病理生理等方面的變化,可為探索行之有效的腦保護(hù)提供幫助,將有助于提高顱腦損傷患者的生存率及生存質(zhì)量。
VCU動(dòng)物顱腦損傷儀分為液壓沖擊損傷儀(FPI),細(xì)胞損傷控制儀(CIC)和電子腦皮質(zhì)挫傷撞擊儀(eCCI)。這三種產(chǎn)品已經(jīng)廣泛應(yīng)用于世界范圍內(nèi)的顱腦創(chuàng)傷研究中心,是目前顱腦創(chuàng)傷模型制作的金標(biāo)準(zhǔn)。同時(shí)FPI損傷儀還可應(yīng)用到眼科損傷模型,CIC細(xì)胞損傷儀可以應(yīng)用到其它種類細(xì)胞損傷模型的制作。
液壓顱腦損傷儀(FPI)
液壓沖擊損傷儀(Fluid Percussion Injury)主要針對(duì)神經(jīng)創(chuàng)傷機(jī)制研究。它成為全球研究神經(jīng)創(chuàng)傷廣泛使用的儀器,可以重復(fù)一致地產(chǎn)生液壓沖擊損傷(FPI)。
系統(tǒng)優(yōu)點(diǎn)：
- 可方便的排除氣泡;
- 角度刻度可方便觀察撞擊角度;
- 集成壓基準(zhǔn)力輸出,方便校準(zhǔn)。
- 精準(zhǔn)輸出沖擊壓力;
- 配備高精度的壓力傳感器
電子顱腦損傷儀(eCCI)
電子大腦皮質(zhì)挫傷撞擊儀 (electric Cortical Contusion lmpactor),主要針對(duì)腦皮質(zhì)挫傷模型,是神經(jīng)損傷研究機(jī)構(gòu)受歡迎的損傷模型制作工具。動(dòng)物平臺(tái)可以和各種立體定位儀搭配使用。
由VCU大學(xué)設(shè)計(jì)制作的電子大腦皮質(zhì)挫傷撞擊儀，主要針對(duì)腦皮質(zhì)挫傷模型。其組件有：堅(jiān)固的鋁架、動(dòng)物平臺(tái)、撞擊控制器和撞擊頭。動(dòng)物平臺(tái)可以和各種立體定位儀搭配使用。由線性馬達(dá)驅(qū)動(dòng)的撞擊頭，可以由控制器來控制撞擊參數(shù)，實(shí)現(xiàn)不同程度的損傷。撞擊頭含有感應(yīng)器，可以確定速率、撞擊深度及撞擊停留。
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與傳統(tǒng)Feeney's自由落體硬膜外撞擊方法相比有以下優(yōu)點(diǎn):可精準(zhǔn)連續(xù)地控制撞擊速度,并獲得實(shí)際撞擊深度和停留時(shí)間等參數(shù),而非重量差異很大的撞擊?？删珳?zhǔn)重復(fù)制作挫傷損傷模型,減少動(dòng)物死亡,使實(shí)驗(yàn)過程更加直觀,可控。
The eCCI is constructed with a sturdy aluminum frame to maximize rigidity, thereby ensuring impact accuracy. The support base, animal platform and impactor head are anodized to prevent oxidation and assure equipment longevity.
Product assembly includes the base and support frame, and adjustable animal positioner with an aluminum animal platform to be used in conjunction with a variety of stereotactic mounts. This model utilizes the enhanced linier motor driven impactor and controller. The enhanced impact head also houses a photo-optic sensor to determine velocity, impact depth and dwell, and is extremely reproducible.
細(xì)胞顱腦損傷儀(CIC)
細(xì)胞損傷控制儀(CI採(cǎi)取電子式控制，適合morphologic、病理理及培養(yǎng)組織損傷后的機(jī)制、形態(tài)學(xué)、病理性。細(xì)胞損傷控制儀是針對(duì)Flexcell Int’l cor tissue culture system。細(xì)胞損傷控制儀平均把壓縮氣體送到每個(gè)culture wells，以造成培養(yǎng)組織牽張性的損傷，損傷的嚴(yán)重程度是依據(jù)氣體在密閉的culture well進(jìn)出的量，細(xì)胞損傷控制儀(CIC)是可以搭配Flex ® 29.45cm2 culturing trays I (針對(duì)VCU早期的細(xì)胞損傷控制儀)和BioFlex® 57.75cm2 culturing trays。因?yàn)楦鶕?jù)所採(cǎi)用的細(xì)胞種類、損傷的程度、培養(yǎng)的狀況，受損后的細(xì)胞或許會(huì)因?yàn)樯鲜鲆蛩厮赖艋蛞拮o(hù)，所以VCU的細(xì)胞損傷控制儀(CIC)很適合應(yīng)用在下列領(lǐng)域:細(xì)胞受損、修護(hù)，死亡，藥介入的反應(yīng)。
Depending on the cell type, the degree of injury and the culture conditions, the injured cells may die or repair. Therefore, the system can be employed to study the responses to trauma, including cell injury, repair, death or pharmacologic intervention.
The CIC II has been designed for use with a patented, commercially available tissue culture system from Flexcell International Corp. in Hillsborough, N.C. Tissue cultures are grown in culturing wells with stretchable Silastic® membrane bottoms. The CIC II regulates the flow of compressed gas to rapidly pressurize individual culture wells, causing a radial stretch injury to the culture. Injury severity is determined by controlling the flow of gas in and out of the sealed culture well and the peak pressure is captured to provide an accurate indicator of radial stretch.
The CIC II accepts both the Flex I® 29.45cm2 culturing trays, which were used with the earlier CIC Model 94A, and the BioFlex® 57.75cm2 culturing trays.
